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Arrakis Therapeutics


Assay Development – Waltham, Massachusetts
Department Assay Development
Employment Type Full-Time

Position Summary:

The mission of Arrakis Therapeutics is to extend small molecule medicines into new realms of biology by discovering and developing compounds that selectively target RNA.  By targeting distinct RNA structures, Arrakis is generating drug candidates with novel mechanisms of action for molecular targets that are challenging to drug in therapeutic indications with high unmet need. 

We are seeking a Scientist in the Biophysics-Mass Spectrometry group to support the discovery of novel small molecule modulators of RNA targets.  The position requires proficiency in multidimensional chromatography and mass spectrometry workflows for high-throughput screening of small molecule libraries.  This is an opportunity to substantively contribute to a vital function of our fast-growing company.

Ph.D. in a relevant scientific field with 3+ years of total relevant experience is required.


  • The responsibilities of this position include but are not limited to the following:
  • Contribute to maintaining multiple multidimensional LC-mass spectometry platforms.  This requires exceptional instrument hygiene, analytical skills and diligent record keeping of platform performance.
  • Design, validate and implement high-throughput small molecule library screens using affinity-based mass spectrometry methods.
  • Be motivated to independently analyze and report data from 100-1000s of small molecule candidates on a routine basis and report progress to team.
  • Work effectively in a cross-functional capacity with the RNA biology, informatics, biology and chemistry teams to deliver high-quality results in an efficient manner.
  • Routine use of an electronic laboratory notebook.
  • Presentations of ideas and results, including technical issues and creative problem solving options, at project team or company-wide meetings.
  • Work with Arrakis colleagues and leadership to ensure that project goals are met.
  • Evaluate and implement new assay approaches as related to high-throughput mass spectrometry technologies.


Skills/Knowledge Required:

  • Experience with small molecule screening in support of medicinal chemistry.
  • Specific experience with liquid chromatography for Orbitrap and/or Q-TOF detection and analysis.
  • Hands-on experience in the independent design and execution of experiments.
  • Strong skills in any of the following areas: analytical chemistry, proteomics, metabolomics.
  • Experience with high throughput screening liquid handing robotics and equipment a plus.
  • Strong computer skills with experience with data analysis and data reporting.
  • Excellent communication, problem solving and collaboration skills. 
  • Strong attention to detail.
  • Ability to interact and communicate effectively with laboratory colleagues, research management, and project team leaders.
  • Ability to effectively manage time and priorities over multiple lines of work.
  • Excellent oral communication and writing skills.
  • Ability to work in a dynamic and changing environment.


Other Characteristics & Traits:

  •  Demonstrates independent, scientifically directed, and innovative thinking.
  • Anticipates the need for contingencies and develops alternative strategies.
  • Role model for scientific excellence.
  • Outstanding team member.


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  • Location
    Waltham, Massachusetts
  • Department
    Assay Development
  • Employment Type
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