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Arrakis Therapeutics

Research Associate / Associate Scientist, Molecular Biology

RNA Biology – Waltham, Massachusetts
Department RNA Biology
Employment Type Full-Time
Minimum Experience Entry-level

Mission:

The mission of Arrakis Therapeutics is to extend small molecule drug discovery into new realms of biology by discovering and developing compounds that selectively target RNA. By targeting specific RNA structure/function relationships, Arrakis will generate drug candidates with novel mechanisms of action for high-value molecular targets that are challenging to address via traditional approaches in therapeutic indications with high unmet medical need.

Generating high-quality RNA constructs for screening, biophysical/biochemical assays, and structural biology efforts is core to the mission at Arrakis. The candidate will support the effort to establish a world-class in vitro transcription (IVT) platform to produce natively folded RNA at scale.

Job Description

  • B.A. / B.S. in Biology, 2+ years experience
  • Drive in vitro transcription platform to generate RNA constructs at scale for various downstream applications.
  • Purify RNA constructs by size-exclusion chromatography (SEC) and perform quality control using polyacrylamide gel electrophoresis, capillary electrophoresis (e.g., Fragment Analyzer), SEC, dynamic light scattering, chemical probing (e.g., SHAPE), and Illumina sequencing
  • Develop and deploy 5- and 3-end labeling methodologies to modify RNA constructs generated via the IVT platform.
  • Work with automated liquid handlers for the high throughput production of RNA constructs.
  • Work effectively with a cross-functional biology, informatics, assay development and chemistry team to deliver high-quality results on aforementioned objectives in an efficient manner.

Core Competencies:

 Fast-acting/efficient. Moves quickly and proactively with a strong work ethic to produce high-quality results while fostering a positive work environment. Able to produce significant output with minimal wasted effort. Focuses on key priorities. Does not let important details slip through the cracks or derail a project. Demonstrates tenacity and willingness to go the distance to get something done.

Integrity. Does not cut corners ethically. Earns trust and maintains confidences. Does what is right not just what is politically expedient. Speaks plainly and truthfully. Follows-through on commitments. Expects personal performance and team performance to be nothing short of world-class.

Intelligence and innovation. Learns quickly. Demonstrates ability to proficiently understand new information. Able to structure and process qualitative and quantitative data and draw insightful conclusions. Exhibits a probing mind and achieves penetrating insights. Generates new and innovative approaches to problems.

Teamwork. Reaches out to peers and cooperates with the team to establish an overall collaborative working environment. Let’s others speak and seeks to understand their viewpoints. Often solicits feedback and reacts calmly to objective feedback. Speaks, writes, and presents clearly without being overly verbose. Able to convince others to pursue a course of action. Able to communicate the big picture in an inspiring way. Exhibits passion and excitement over work. Has a can-do attitude without losing objectivity.

Flexibility/adaptability. Adjusts quickly to changing priorities and conditions. Copes effectively with complexity and change. Calm under pressure.

Technical proficiency. Strong In the areas of molecular biology, cell biology and biochemistry with an emphasis on methodologies highlighted in the Key Outcomes section.

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  • Location
    Waltham, Massachusetts
  • Department
    RNA Biology
  • Employment Type
    Full-Time
  • Minimum Experience
    Entry-level
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