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Arrakis Therapeutics

Research Associate

Target Biology and translational medicine – Waltham, Massachusetts
Department Target Biology and translational medicine
Employment Type Full-Time
Minimum Experience Entry-level

 

Position Summary:

The mission of Arrakis Therapeutics is to extend small molecule medicines into new realms of biology by discovering and developing compounds that selectively target RNA (“rSMs”).  By targeting distinct RNA structures, Arrakis is generating drug candidates with novel mechanisms of action for molecular targets that are challenging to drug in therapeutic indications with high unmet need. 

Cell based assay development and in-cell evaluation of high priority targets are critical to realizing Arrakis’ mission. We are seeking a talented RA/Senior RA to assist in development and validation of new cell-based assays for high throughput screening and provide tissue culture support to aid critical projects. This role will leverage a broad array of tissue culture techniques including cutting-edge techniques such as CRISPR editing.  We seek a team player who is committed to carrying out robust science and can matrix with cross-functional groups in a fast-paced environment. The ideal candidate will have a BA/BS in biology or related field and previous industry experience. Expertise in basic cell culture methods including passaging, maintaining and plating cell lines is required. Prior experience with cell transfection techniques, lentiviral production and infection, and basic use of FACS (4-color) is strongly preferred.

Responsibilities of the Role:

  • Assist the development and validation of new cell-based assays
  • Support other vital tissue culture needs of the team
  • Work collaboratively within the Target Biology and Translational Medicine team and matrix with the Assay team to deliver high-quality assays and results in a timely and efficient manner

Required Experience/Skills/Knowledge:

  • BA/BS in Biology or related field
  • Expertise in tissue culture including a demonstrated ability to: a) culture and maintain cell lines and b) design and execute well-controlled tissue culture experiments
  • Ability to effectively communicate methodologies and results with management and colleagues
  • Strong problem-solving and trouble-shooting skills
  • Excellent oral communication and writing skills
  • Ability to work in a dynamic and fast-paced environment, and willingness to quickly adapt and learn new techniques

 

Preferred Experience/Skills/Knowledge:

  • Previous industrial experience (3+ years)
  • Experience in lentiviral production and infection is highly desired
  • Prior experience in mammalian cell transfection techniques is a plus
  • Experience with basic FACS analysis and cell sorting (up to 4-color)
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  • Location
    Waltham, Massachusetts
  • Department
    Target Biology and translational medicine
  • Employment Type
    Full-Time
  • Minimum Experience
    Entry-level
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