Do you have the passion to join a group whose mission is to pioneer the discovery of a new class of medicines to treat diseases unaddressed by today’s medicines? Does it excite you to be a part of a company with a focus on cancer and genetically-validated targets in other disease areas with unmet medical need? If yes, you may be a great fit to join Arrakis on our path to bring powerful new therapies to millions of patients.
Your Impact at Arrakis
The mission of Arrakis Therapeutics is to extend small molecule medicines into new realms of biology by discovering and developing compounds that selectively target RNA (“rSM”). By targeting distinct RNA structure/function relationships, Arrakis is generating drug candidates with novel mechanisms of action for molecular targets that are challenging to drug in disease areas with high unmet medical need.
This is an opportunity to participate in a small molecule drug development to deliver novel cancer therapeutics to the clinic. Decades of cancer genetics combined with modern multi-omic analyses of tumors have yielded rich understanding of aberrant signaling as well as key dependencies in cancer. Many of these well-validated dependencies have been difficult to drug at the protein level. Our platform aims to unlock these high-value targets using small molecules to ligand mRNA structures. The Oncology scientist will participate in driving the experimental biology of a target-specific program from inception through preclinical proof-of-concept in model organisms. The Scientist, Oncology will make a large impact on the Arrakis mission through their role in driving the biology of the target-specific experiments required to progress newly identified chemical hits through lead identification. The role spans design and development of cell-based assays, target validation and mechanism of action characterization of high value series in cells. The successful candidate will leverage functional genomics and/or derive cell lines with inducible degrons to assess the extent of target perturbation required for eliciting cell death, characterize effects on key downstream pathways and identify biomarkers for use in pharmacodynamic assessments.
Deep expertise in mechanisms and pathways that drive transformation and the ability to consider mechanistic implications of targeting RNA biology in elaborating the biological strategy are key requirements for this role. In addition, the ability to function in a cross-functional manner across teams with diverse expertise are critical to success in this position.
The ideal candidate will enjoy working in a collaborative, fast-paced start-up environment, leveraging a high degree of problem-solving and troubleshooting skills to make a large impact on our mission.
Arrakis is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, national origin or ancestry, sex, pregnancy, sexual orientation, gender identity, age, disability, military service, veteran status, genetic information, or any other characteristic protected by law.
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