Research Associate, Biophysics and Assay Development

Biophysics & Assay Development · Waltham, Massachusetts
Department Biophysics & Assay Development
Employment Type Full-Time
Minimum Experience Entry-level

Do you have the passion to join a group whose mission is to pioneer the discovery of a new class of medicines to treat diseases unaddressed by today’s medicines?  Does it excite you to be a part of a company with a focus on cancer and genetically-validated targets in other disease areas with unmet medical need?  If yes, you may be a great fit to join Arrakis on our path to bring powerful new therapies to millions of patients.  


Your Impact at Arrakis


The mission of Arrakis Therapeutics is to extend small molecule medicines into new realms of biology by discovering and developing compounds that selectively target RNA (“rSM”). By targeting distinct RNA structure/function relationships, Arrakis is generating drug candidates with novel mechanisms of action for molecular targets that are challenging to drug in disease areas with high unmet medical need.  


We are seeking a Research Associate in the Biophysics and Assay Development group to support the discovery of novel small-molecule modulators of RNA targets.  The position requires good working knowledge of binding, thermodynamics and equilibrium, and kinetics.  This is an opportunity to substantively contribute to a vital function of our fast-growing company.  The ideal candidate will enjoy working in a collaborative, fast-paced start-up environment, leveraging a high degree of integrity, intelligence and innovation to make a large impact on our mission.  


Job Responsibilities:


  • Contribute to screening of small-molecule and RNA interactions by SPR, MST, FP, and other assays as needed.  
  • Design, validate and implement moderate- to high-throughput screens.
  • Be motivated to independently analyze and report data from 100-1000s of small molecule candidates on a routine basis and report progress to team.
  • Work effectively in a cross-functional capacity with the RNA biology, informatics, biology and chemistry teams to deliver high-quality results in an efficient manner.
  • Presentations of ideas and results, including issues & possible solutions, at project team or company-wide meetings.
  • Work with Arrakis colleagues and leadership to ensure that project goals are met.
  • Evaluate and implement new assay approaches as related to high-throughput RNA-small-molecule interactions. 



  • B.S. in Biochemical Sciences, Physical Chemistry or related field with 0-1 years of applicable research experience or M.S. in Biochemical Sciences 
  • Experience in the theory, independent design, and/or prosecution of a range of in vitro binding assay assays. This will include experience in data handling and analysis. 
  • Experience with lab automation.
  • Ability to execute independently with little direction but also to thrive in a multidisciplinary team environment.
  • Ability to effectively communicate methodologies and results with management and colleagues.
  • Ability to adjust quickly to changing priorities and conditions and cope effectively with complexity and change.
  • Proactive and efficient to enable high-quality results while ensuring optimal use of resources within assigned program(s).
  • Fosters a positive and collaborative work environment across research functions.


Arrakis is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, national origin or ancestry, sex, pregnancy, sexual orientation, gender identity, age, disability, military service, veteran status, genetic information, or any other characteristic protected by law.


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  • Location
    Waltham, Massachusetts
  • Department
    Biophysics & Assay Development
  • Employment Type
  • Minimum Experience