Associate Director / Director, Head of Cellular Screening

Biophysics & Assay Development · Waltham, Massachusetts
Department Biophysics & Assay Development
Employment Type Full-Time
Minimum Experience Senior Manager/Supervisor

Do you have the passion to join a group whose mission is to pioneer the discovery of a new class of medicines to treat diseases unaddressed by today’s therapies?  Does it excite you to be a part of a company with a focus on cancer and genetically-validated targets in other disease areas with unmet medical need?  If yes, you may be a great fit to join Arrakis on our path to bring powerful new therapies to millions of patients.

 

Your Impact at Arrakis

 

The mission of Arrakis Therapeutics is to extend small molecule medicines into new realms of biology by discovering and developing compounds that selectively target RNA (“rSM”). By targeting distinct RNA structure/function relationships, Arrakis is generating drug candidates with novel mechanisms of action for molecular targets that are challenging to drug in disease areas with high unmet medical need. 

 

The Head of Cellular Screening has the unique opportunity to create a vision and implement strategy that will make a major impact on the emerging RNA/rSM field. The successful candidate will report to the SVP Discovery and lead a group of up to 6 scientists and/or associate scientists. The remit of this group is to enable validation, automation, and execution of new cell-based assays in support of Arrakis programs.  

 

The ideal candidate is a strong leader and skilled manager and will enjoy working in a collaborative, fast-paced start-up environment, leveraging a high degree of problem-solving and troubleshooting skills to make a large impact on our mission.   

 

Managerial responsibilities:

 

  • Create the vision for and develop a state-of-the-art cellular screening capability at Arrakis
  • Establish and manage workflows for cell-based assay screening that provide high-quality, timely data to discovery programs and integrate the latest technology advances.
  • Develop and maintain the group’s infrastructure to ensure optimal use of resources with the cell screening function.
  • Lead a group of up to 6 direct or indirect reports. Provide coaching and leadership to facilitate effective solutions for direct reports, projects and the functional area.
  • Member of the Arrakis Senior Management Team. Actively participate in cross functional discussions to review, prioritize and advance Arrakis R&D portfolio.
  • Foster a positive and collaborative work environment across research functions.

 

Qualifications:

 

  • MSc or PhD in biological sciences
  • 10+ years of applicable industry experience with an excellent scientific track record
  • Expert in compound screening formats, especially plate-based cell assays (HiBit, HTRF, Alpha Screen, qRT-PCR, MSD). Proficient with laboratory instrumentation and automation, data analysis and management.
  • Sound knowledge of the drug discovery process
  • Experience with cell line development and validation
  • Proven track record in establishing new technologies and scientific excellence in an industry setting
  • Requires experience as a supervisor and coach of multiple scientists
  • Experience in leading a cross-functional team in an industry setting is desirable
  • Experience with high content screening desirable

 

Arrakis is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, national origin or ancestry, sex, pregnancy, sexual orientation, gender identity, age, disability, military service, veteran status, genetic information, or any other characteristic protected by law.

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  • Location
    Waltham, Massachusetts
  • Department
    Biophysics & Assay Development
  • Employment Type
    Full-Time
  • Minimum Experience
    Senior Manager/Supervisor