Senior Scientist, Target Validation (Target Biology and Translational Medicine)

Target Biology and translational medicine · Waltham, Massachusetts
Department Target Biology and translational medicine
Employment Type Full-Time
Minimum Experience Senior Manager/Supervisor

Do you have the passion to join a group whose mission is to pioneer the discovery of a new class of medicines to treat diseases unaddressed by today’s medicines?  Does it excite you to be a part of a company with a focus on cancer and genetically-validated targets in other disease areas with unmet medical need?  If yes, you may be a great fit to join Arrakis on our path to bring powerful new therapies to millions of patients.  


Your Impact at Arrakis


The mission of Arrakis Therapeutics is to extend small molecule medicines into new realms of biology by discovering and developing compounds that selectively target RNA (“rSM”). By targeting distinct RNA structure/function relationships, Arrakis is generating drug candidates with novel mechanisms of action for molecular targets that are challenging to drug in disease areas with high unmet medical need.  


The Senior Scientist, Target Validation will make a large impact on Arrakis mission by building a small team to drive target validation to fuel the Arrakis pipeline.  The successful candidate will build and lead a group to implement an expanding array of assays to interrogate key elements of target biology in therapeutically relevant cell lines.  A background in oncology and/or rare genetic disease biology are strongly preferred.  This role with matrix closely with (1) therapeutic area scientists to coordinate timely cell-based assay development and (2) RNA biologists to integrate platform learnings into target validation processes.  The ability to function in a cross-functional manner across teams with diverse expertise and to lead research associates and/or scientists are critical to success in this position. 


The ideal candidate will enjoy working in a collaborative, fast-paced start-up environment, leveraging a high degree of problem-solving and troubleshooting skills to make a large impact on our mission.  


Job Responsibilities:


  • Drive efficient experimental assessment of key elements of target biology across cell lines of interest and nominate cell lines for cell-based assay development
  • Recruit, hire and supervise a small group of Research Associates and/or Scientists to scale target validation scope and throughput over time
  • Implement assays on a rolling basis to integrate platform learnings to increase sophistication of target validation 
  • Identify and manage CROs to enable additional bandwidth and/or capabilities where appropriate
  • Assess MOA hypotheses of mRNA-level regulation of target genes in various cell lines upstream of programs
  • Work collaboratively within the Target Biology and Translational Medicine team and matrix across the organization to progress projects in a timely and efficient manner. 
  • Contribute to a culture of open and effective collaboration between experimental and computational scientists.




  • PhD in Biology, Genetics or related field with 5+ years of industry experience
  • Expertise analyzing intracellular biology at the protein and mRNA level using a range of techniques
  • Experience driving and delivering research to meet timelines, including strategic use and management of CROs
  • Demonstrated ability to effectively supervise, inspire, and develop research associates and/or scientists.
  • Experience performing and analyzing a broad array of molecular and cellular biological methods (qRT-PCR, capillary electrophoresis WES/JES, NGS methods and readouts)
  • Ability to effectively communicate methodologies, results and program status with colleagues, including scientists, research management, project team leaders and advisors.
  • Exhibits curiosity, passion and excitement for science. Has a can-do attitude without losing objectivity.
  • Adjusts quickly to changing priorities and conditions and copes effectively with complexity and change. 


Arrakis is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, national origin or ancestry, sex, pregnancy, sexual orientation, gender identity, age, disability, military service, veteran status, genetic information, or any other characteristic protected by law.

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  • Location
    Waltham, Massachusetts
  • Department
    Target Biology and translational medicine
  • Employment Type
  • Minimum Experience
    Senior Manager/Supervisor