Scientist, RNA Production

RNA Biochemistry · Waltham, Massachusetts
Department RNA Biochemistry
Employment Type Full-Time
Minimum Experience Manager/Supervisor

Do you have the passion to join a group whose mission is to pioneer the discovery of a new drug class to treat diseases unaddressed by today’s medicines?  Does it excite you to be a part of a company with a focus on cancer and genetically-validated targets in other disease areas with unmet medical need?  If yes, you may be a great fit to join Arrakis on our path to bring powerful new therapies to millions of patients.


 


Your Impact at Arrakis


 


The mission of Arrakis Therapeutics is to extend small molecule drug discovery into new realms of biology by discovering and developing compounds that selectively target RNA. By targeting specific RNA structure/function relationships, Arrakis will generate drug candidates with novel mechanisms of action for high-value molecular targets that are challenging to address via traditional approaches in therapeutic indications with high unmet medical need.  


 


Generating high-quality RNA constructs for screening, biophysical/biochemical assays, and structural biology efforts is core to the mission at Arrakis. The candidate will lead our effort to establish a world-class in vitro transcription (IVT) platform to produce natively folded RNA at scale. The ideal candidate will enjoy leading a small team in a collaborative, fast-paced start-up environment, leveraging a high degree of integrity, intelligence and innovation to make a large impact on our mission.  


 


Job Responsibilities:


 


  • Lead a group of one to three associates developing and applying our in vitro transcription (IVT) production platform.
  • Coordinate RNA production efforts with other groups and project teams through efficient processes for requesting RNA, reporting QC results, and transferring material.
  • Develop novel methods for producing natively folded RNA at scale, including 5′- and 3′-end labeling, structural analysis, and automation.
  • Guide the optimization of methods for RNA synthesis, purification, and quality control, including IVT, size-exclusion chromatography, chemical probing (e.g., SHAPE), capillary electrophoresis, and next-generation sequencing.
  • Develop the careers of members of the production team.
  • Work effectively with a cross-functional biology, informatics, assay development, and chemistry team to deliver high-quality results on aforementioned objectives in an efficient manner. 


 


Requirements:


  • B.S. in Biology, Biochemistry, or a related field with at least 7 years of industry experience; M.S. with at least 5 years of industry experience; or Ph.D. with at least 1 year of industry experience.
  • Management experience.
  • Extensive experience working with RNA and performing in vitro transcription reactions. 
  • Experience with size exclusion chromatography strongly preferred. 
  • Experience with chemical probing of RNA structure (e.g., SHAPE) and next-generation sequencing preferred, but not required. 
  • Proactive and efficient to enable high-quality results while fostering a positive work environment.
  • Exhibits passion and excitement over work. Has a can-do attitude without losing objectivity.
  • Adjusts quickly to changing priorities and conditions and copes effectively with complexity and change. 


 


Arrakis is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, national origin or ancestry, sex, pregnancy, sexual orientation, gender identity, age, disability, military service, veteran status, genetic information, or any other characteristic protected by law.

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  • Location
    Waltham, Massachusetts
  • Department
    RNA Biochemistry
  • Employment Type
    Full-Time
  • Minimum Experience
    Manager/Supervisor