Do you have the passion to join a group whose mission is to pioneer the discovery of a new class of medicines to treat diseases unaddressed by today’s medicines? Does it excite you to be a part of a company with a focus on cancer and genetically-validated targets in other disease areas with unmet medical need? If yes, you may be a great fit to join Arrakis on our path to bring powerful new therapies to millions of patients.
Your Impact at Arrakis
The mission of Arrakis Therapeutics is to extend small molecule medicines into new realms of biology by discovering and developing compounds that selectively target RNA (“rSM”). By targeting distinct RNA structure/function relationships, Arrakis is generating drug candidates with novel mechanisms of action for molecular targets that are challenging to drug in disease areas with high unmet medical need. Our primary focus is to target structures within mRNA to modulate the expression of disease-driving genes that are not druggable at the protein level.
The Senior Scientist, Target Biology will make a large impact on Arrakis mission by building a small team to drive the build of therapeutically relevant cell assays based on disease biology and detailed target characterization. Arrakis is scaling efforts to build more cell-based assays to power a fast-growing number of programs. This role requires the ability to manage parallel processes and data streams generated by direct reports and CROs to deliver assays in a timely manner to the screening group. The successful candidate will explore a broad array of disease biology, with primary focus in oncology and immunology. This individual will oversee both the building of a knowledge base in specific disease target biology as well as the generation of cell-based assays to monitor the effects of hit and lead compounds on target expression and downstream biology. A background in oncology, immunology, rare genetic disease and/or neurobiology are strongly preferred. This role will matrix closely with (1) therapeutic area scientists to inform biology where applicable, (2) RNA biologists to integrate platform learnings into the selection of target vulnerabilities including the modulation of translation and splicing, (3) the bioinformatics team to analyze data where necessary (4) the screening team who are the end users and (5) external collaborators where appropriate. The successful candidate will contribute to our large collaboration with Roche which applies the Arrakis RNA-targeting platform across every therapeutic area within Roche. The ability to function in a cross-functional manner across teams with diverse expertise and demonstrated management experience to lead research associates and/or scientists are critical to success in this position.
The ideal candidate will enjoy working in a collaborative, fast-paced start-up environment, leveraging a high degree of problem-solving and troubleshooting skills to make a large impact on our mission.
Arrakis is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, national origin or ancestry, sex, pregnancy, sexual orientation, gender identity, age, disability, military service, veteran status, genetic information, or any other characteristic protected by law.
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