Associate Scientist, Next Generation Sequencing

RNA Biochemistry · Waltham, Massachusetts
Department RNA Biochemistry
Employment Type Full-Time
Minimum Experience Experienced

Do you have the passion to join a group whose mission is to pioneer the discovery of a new class of medicines to treat diseases unaddressed by today’s therapies? Does it excite you to be a part of a company with a focus on cancer and genetically-validated targets in other disease areas with unmet medical need? If yes, you may be a great fit to join Arrakis on our path to bring powerful new therapies to millions of patients. 

Your Impact at Arrakis

 

The mission of Arrakis Therapeutics is to extend small molecule medicines into new realms of biology by discovering and developing compounds that selectively target RNA (“rSM”). By targeting distinct RNA structure/function relationships, Arrakis is generating drug candidates with novel mechanisms of action for molecular targets that are challenging to drug in disease areas with high unmet medical need. 

 

Arrakis uses a diverse array of chemical biology techniques to evaluate rSMs. These techniques range from in vitro biochemical assays coupled with next-generation sequencing (NGS), to assays in cell culture, all with the goal of compiling data for rSM-RNA binding and molecular mechanism. You will be part of a team of researchers carrying out cutting edge research to forge a new path in therapeutics. Accordingly, we value those who are flexible and adaptable to new challenges and techniques. The ideal candidate will enjoy working in a collaborative, fast-paced start-up environment, leveraging a high degree of integrity, intelligence and innovation to make a large impact on our mission.

 

Job Responsibilities:

 

  • Perform large scale, multiplexed experiments including RNA crosslinking and RNA chemical probing (with SHAPE reagents or equivalent).
  • Perform NGS library preparation on in vitro RNA.
  • Develop novel or adapt existing NGS library preparation methods to enable novel assays of rSM binding.
  • Perform Illumina sequencing on a MiSeq instrument and interface with computational biologists to transfer data and sample information.
  • Generate new and innovative approaches to problems by exhibiting a probing mind and penetrating insights.
  • Carefully document experiments in an electronic lab notebook and communicate results to collaborators.
  • Work effectively with a cross-functional biology, informatics, assay development and chemistry team to deliver high-quality results in an efficient manner.

 

Requirements:

 

  • B.S. in Molecular Biology, Biochemistry or Biology with 5+ years of relevant industry experience or Master’s degree with 3+ years of relevant industry experience.
  • Demonstrated ability to establish NGS methods and perform sequencing-based assays.
  • Extensive experience with NGS library preparation.
  • Detailed knowledge of library preparation to allow method adaptation for specific tasks with minimal supervision.
  • Experience in chemistry or chemical biology.
  • Experience with mammalian cell culture a plus.
  • Ability to work both independently with minimal supervision and cooperatively as part of a team.
  • Proactive and efficient to enable high-quality results while fostering a positive work environment.
  • Exhibits passion and excitement over work. Has a can-do attitude without losing objectivity.
  • Adjusts quickly to changing priorities and conditions and copes effectively with complexity and change.

 

 

Interested in learning more about Arrakis?  Click on the links below!

 

https://arrakistx.com/arrakis-achieves-escape-velocity/

                                                                                                                

https://arrakistx.com/following-our-pole-star-to-a-transformative-collaboration/

 

https://www.biopharmadive.com/news/arrakis-roche-deal-drugging-rna/575695/

 

https://xconomy.com/boston/2020/04/08/roche-pays-190m-to-start-rna-drug-alliance-with-arrakis-therapeutics/

 

Arrakis is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, national origin or ancestry, sex, pregnancy, sexual orientation, gender identity, age, disability, military service, veteran status, genetic information, or any other characteristic protected by law.

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  • Location
    Waltham, Massachusetts
  • Department
    RNA Biochemistry
  • Employment Type
    Full-Time
  • Minimum Experience
    Experienced